Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides
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چکیده
منابع مشابه
Enantioselective amine α-functionalization via palladium catalyzed C–H arylation of thioamides
Saturated aza-heterocycles are highly privileged building blocks that are commonly encountered in bioactive compounds and approved therapeutic agents. These N-heterocycles are also incorporated as chiral auxiliaries and ligands in asymmetric synthesis. As such, the development of methods to functionalize the α-methylene C-H bonds of these systems enantioselectively is of great importance, espec...
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ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2016
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.2619